Abby Lei 04.26.2016
The voltage-dependent
anion channel (VDAC), also
known as mitochondrial porin, is the most abundant protein in the
mitochondrial outer membrane (MOM).
VDAC is the channel
known to guide the metabolic flux across the MOM and plays a key role in
mitochondrially induced apoptosis.It behaves as a general diffusion pore
for small hydrophilic
molecules. The channel adopts an open conformation at low or zero
membrane potential and a closed conformation at potentials above 30-40
mV.
VDAC facilitates the
exchange of ions and molecules between mitochondria and cytosol and is
regualted by the interactions with other proteins and small molecules.
| The Overview
of VDAC Structure |
Page 1 |
| Similarity
between VDAC and bacterial porin |
Page 2 |
| Specific
structures inside VDAC |
Page 3 |
| Opening and
Closing conformations of VDAC |
Image 4 |
| The functions
of VDAC |
Page 5 |